In a neonate with a ductal-dependent lesion, which medication is used to maintain ductus arteriosus patency?

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Multiple Choice

In a neonate with a ductal-dependent lesion, which medication is used to maintain ductus arteriosus patency?

Explanation:
Maintaining ductus arteriosus patency in a neonate with a ductal-dependent lesion requires a medication that keeps the ductus open by relaxing its smooth muscle. Prostaglandin E1 (alprostadil) does this effectively, preserving the flow through the ductus to support circulation until a surgical or other definitive solution is available. Indomethacin, on the other hand, inhibits prostaglandin synthesis and promotes closure of the ductus, which would worsen patency in these cases. Oxygen tends to promote ductal closure by increasing oxygen tension and reducing prostaglandin levels. Morphine does not influence ductus patency in this context.

Maintaining ductus arteriosus patency in a neonate with a ductal-dependent lesion requires a medication that keeps the ductus open by relaxing its smooth muscle. Prostaglandin E1 (alprostadil) does this effectively, preserving the flow through the ductus to support circulation until a surgical or other definitive solution is available.

Indomethacin, on the other hand, inhibits prostaglandin synthesis and promotes closure of the ductus, which would worsen patency in these cases. Oxygen tends to promote ductal closure by increasing oxygen tension and reducing prostaglandin levels. Morphine does not influence ductus patency in this context.

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